CURRENT RESEARCH ACTIVITIES
Fluorescence nanoscopy methods, such as STORM and STED, have revolutionazed biological imaging because they provide a spatial resolution of 10 – 40 nm while keeping the low-invasiveness of far-field optical interrogation. We develop new methods, such as MINFLUX, and open-source software for fluorescence nanoscopy. In collaboration with colleagues of the life sciences, we apply fluorescence nanoscopy and single molecule methods to address questions of cellular biology.
Nanofabrication by self-assembly.
DNA origami technology makes use of the specific supramolecular assembly of DNA to construct nanostructures of practically arbitrary shapes. We have been applying this technology to fabricate hybrid nanostructures containing metallic nanoparticles and photo-active molecules in well defined geometries. Currently, we investigate a possible extension of this apprach using protein supra-molecular assembly.